Shayna Mallett

Computer science

Hometown: Los Alamos, New Mexico, United States

Graduation date: Spring 2022

Health icon, disabled. A red heart with a cardiac rhythm running through it.

FURI | Spring 2022

Graph-Guided Assembly and Typing of the HLA Alleles from RNA-seq Data

Human Leukocyte Antigens (HLA) are encoded by a polymorphic set of genes where even a single base change can impact the function of the body’s immune response to foreign antigens (Gao, 2001). Although many methods exist to type these alleles using whole-genome sequencing, few can use the more popular RNA sequencing with its inconsistency in coverage, and none of these allow for novel allele discovery. Using partially ordered graphs to project sequenced data onto the known alleles will allow for accurate and efficient typing of HLA with flexibility for discovering new alleles and tolerance for poor sequence quality.


View the poster
QR code for the current page

It’s hip to be square.

Students presenting projects at the Fulton Forge Student Research Expo are encouraged to download this personal QR code and include it within your poster. This allows expo attendees to explore more about your project and about you in the future. 

Right click the image to save it to your computer.

Additional projects from this student

Accurately and efficiently typing human leukocyte antigen alleles is essential to successful organ transplants and has potential for precision medicine.


  • FURI
  • Fall 2021