FURI | Spring 2021

Simulation-Guided Preparation of 3D In Vitro Models with Predictable Oxygen Distribution

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Tissue oxygenation is an emerging area of study as knowledge suggests that hypoxia plays a key role in the progression of various diseases including cancer, stroke, and traumatic injuries. This research aims to create a 3D in vitro model that allows quantitative mapping of the pO2 distribution within a 3D cell culture with MRI. In-silico results of the O2 sensitive 3D-MR scaffold (O2S3DMRS) were obtained through COMSOL Multiphysics. This is useful for hypoxia research as it allows monitoring the dynamic pO2 profile within the tissue, providing insights into the cellular responses of hypoxia while assessing other reliable MR imaging agents.

Student researcher

Talia Hertzberg

Biomedical engineering

Hometown: Phoenix, Arizona, United States

Graduation date: Spring 2022