FURI | Spring 2020

Quantification of Tissue Oxygenation to Improve Encapsulated Cell Viability In Vivo

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The long-term goal of this research is to transplant encapsulated beta cells into a diabetic recipient and eliminate insulin injections. Beta cells succumb easily to hypoxic environments. To test oxygen levels non-invasively, we are using oxygen-sensitive nanoprobes that give off a readable signal detected by using H-MRI. The thrust of the research so far has been to test the feasibility of encapsulating a nanoprobe emulsion in a hydrogel. The research team tested various nanoprobe emulsion concentrations for retention within the encapsulation hydrogel, and verified that this nanoprobe formulation is plausible to use in hydrogels.

Student researcher

Michael Alec Finocchiaro

Biomedical engineering

Hometown: Scottsdale, Arizona, United States

Graduation date: Spring 2021