FURI | Spring 2023
PiTE II: TCR-epitope Binding Affinity Prediction with Contribution From CDR3-Alpha, V, and J Genes
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Accurate prediction of the binding affinity between T cell receptor (TCR) and antigen pairs is essential for developing immunotherapy strategies. Historically, prediction models considered only the complementary-determining region 3 (CDR3) of the beta chain of the TCR, but recent developments have shown that incorporating more regions of the TCR in the prediction model can lead to improved accuracy.
Student researcher
Shreyas Sharma
Computer science
Hometown: Phoenix, Arizona, United States
Graduation date: Spring 2023