FURI | Spring 2019

Liquid Embolic Synthesis for Aneurysm Occlusion

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The objective of this research is to create an injectable liquid embolic that can degrade as tissue is regenerated for the treatment of cerebral aneurysms. To achieve this, a Michael Addition is formed upon injection of Poly(N-Isopropilacrylamide-co-GAPGLF Acrylate) [Poly(NIPAAm-co-GAPGLF-Ac] and pentaetythritol tetrakis 3-mercaptopriopionate [QT] at 37°C with a neutral pH, resulting in a gelation. Due to the gelation occurring, the copolymer proves to be an ideal candidate for a liquid embolic that is deliverable in water, is hydrophobic, and can degrade a based on enzymes from regenerating tissue.