MORE | Fall 2018

Investigating Cancer Cell Death and Cell-Signaling Pathways using HSP90 Inhibition and APE1 Inhibition

Numerous studies have targeted the primary survival pathway of various cancers. Unfortunately, cancer cells undergo mutation and find alternative routes of survival. The aim of this research is to target various cancer survival pathways. Specifically, the inhibition of heat shock protein 90 (HSP90) and apurinic/apyrimidinic endonuclease 1 (APE1) will be investigated. In addition to achieving high cancer cell death, this research sheds light on cancer cell-signaling pathways associated with activator protein 1 (AP-1) and phosphatase and tensin homolog (PTEN).