FURI | Spring 2021

Interictal Spike Depolarization in the Neocortex: Relationship to Action Potential Inactivation

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Evaluated how local voltage changes due to interictal spikes impact action potential firing using intracellular recordings and the Hodgkin-Huxley model. The Hodgkin-Huxley model showed inactivated action potentials being generated by large depolarizations. The Hodgkin-Huxley model confirmed the effect of large interictal spike depolarizations on action potential firing and inactivation. This supports the hypothesis that interictal spikes may contribute to idiopathic seizure disorder.

Student researcher

Lauren Lossner

Lauren Nicole Lossner

Biomedical engineering

Hometown: Mesa, Arizona, United States

Graduation date: Spring 2021