FURI | Spring 2019

Impact of Electrospun Nanoscaffold Morphology on Cell Fate to Optimize Tissue Regenerative Response

The research objective is to fabricate tunable electrospun nanoscaffolds and analyze their morphology to determine if it is feasible to design an implantable 3D substrate to induce tissue regeneration. Prototypical implantable scaffolds were fabricated from a polymer solution that was propelled via an electric field under set conditions to form electrospun fibers. Scanning electron microscopy characterizes key nanoscaffold properties for tissue regeneration.  This research is important to clinical applications when directing the differentiation of cells in new tissue. Future work includes seeding cells onto scaffolds to determine which characteristics are most significant to cell outcomes.