FURI | Spring 2019

Engineering of High Yield Production of L-Serine in Cyanobacteria

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Cyanobacteria have the potential to efficiently produce L-serine, an industrially important amino acid, directly from CO2 and sunlight, which is a more sustainable and cheaper source of energy as compared to current methods. The research aims to engineer a strain of cyanobacteria that increases L-serine production by mutating regulatory mechanisms that natively inhibit its production, overexpressing the needed bio-synthetic genes, and encoding a serine exporter. After the creation of the strain, L-serine levels will be tracked using liquid chromatography. The work can be extended by deletion of genes that are involved in the amino acid’s degradation.

Student researcher

Omar Abed

Omar Abed

Chemical engineering

Hometown: Maricopa, Arizona, United States

Graduation date: Spring 2020