KEEN, MORE | Spring 2020

Engineering an Encapsulated 3D Tumor Dormancy Model In Vivo Using NRAS-Mutant Melanoma Cells

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Two-dimensional entrapment of tumor cells to study dormancy has been studied before using ECM-induced, cell signaling-induced, biochemical-induced, etc. modes for cancers such as prostate, lung, colorectal, pancreatic, etc. in vitro, but not in vivo. Due to the lack of three-dimensional (3D) in vivo models for such studies, this project hypothesizes that a 3D tumor dormancy model can be formed using polymer-based encapsulation of melanoma and breast tumor cells. This model consists of tumor cells cultured on a novel hydrogel platform to form spheroids to induce dormancy and their physical confinement by encapsulation in amikabeads, followed by injection and treatment in vivo.

Student researcher

Tanya Nanda

Biomedical engineering

Hometown: Tempe, Arizona, United States

Graduation date: Fall 2020