FURI | Summer 2020
Directed Evolution for Biological Sensors
Complex synthetic biology methods demand the integration of continuous culture, directed evolution, and positive/negative selection methods. To achieve this in a single platform, the research team built an open source multiplexed bioreactor (eVOLVER) and modified it to function as a directed evolution system. Modifications include a turbidostat, for continuous feed of bacteria into experiments, and a two-lagoon system, allowing for both positive and negative selection. The team has developed a theoretical system that is currently being implemented to create the physical system. Once established, this technology will be the basis for next generation biological sensors and bioactive proteins.
Student researcher
Maren C Eltze
Biomedical engineering
Hometown: Tucson, Arizona, United States
Graduation date: Spring 2021