FURI | Spring 2019

Liquid Embolic Synthesis for Aneurysm Occlusion

The objective of this research is to create an injectable liquid embolic that can degrade as tissue is regenerated for the treatment of cerebral aneurysms. To achieve this, a Michael Addition is formed upon injection of Poly(N-Isopropilacrylamide-co-GAPGLF Acrylate) [Poly(NIPAAm-co-GAPGLF-Ac] and pentaetythritol tetrakis 3-mercaptopriopionate [QT] at 37°C  with a neutral pH, resulting in a gelation. Due to the gelation occurring, the copolymer proves to be an ideal candidate for a liquid embolic that is deliverable in water, is hydrophobic, and can degrade a based on enzymes from regenerating tissue.