Isaac Coello Dantus
Mechanical engineering
Hometown: Mexico City, State of Mexico, Mexico
Graduation date: Spring 2024
FURI | Spring 2024
Deconvolution of the Mechanical Effects in Atomic Force Microscopy Material Characterization of Living Cells
Atomic Force Microscopy (AFM) has been extensively used to determine the mechanical properties of materials ranging from ceramics to soft living tissue. There is an increasing use of AFM for the characterization of biological structures, which have been developed into new diagnostic techniques. However, the effects of cell size, substrate and inclusion presence on AFM measurements have not been exhaustively investigated. This study aims to understand these effects through Finite Element Analysis of a size varying cell resting on a glass substrate. The result is a relationship between the height of the cell and the indentation depth necessary for accurate measurements.
Mentor: Masoud Yekani Fard
It’s hip to be square.
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